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Ancient DNA and Isotopes Reveal Roman Italian Ancestry and Family Relationships

McMaster Researcher reveal complex population dynamics in the wake of Roman subjugation of the Italian Peninsula (3rd century BCE)

Antibiotic resistance is ancient

This work illustrates that antibiotic resistance is a naturally occurring, widespread phenomenon that predates our extensive use of antibiotics. This is ...

Complete Columbian mammoth mitogenome suggests interbreeding with woolly mammoths

Here we report the first complete mitochondrial genomes of a Columbian mammoth (Mammuthus columbi) and a North American Woolly mammoth (Mammuthus primigenius). ...

Collapse of the mammoth-steppe in central Yukon as revealed by ancient environmental DNA

Ancient environmental DNA reconstructs the Pleistocene-Holocene ecological transition using permafrost sediments from central Yukon and finds evidence for the ...

Probe design for simultaneous, targeted capture of diverse metagenomic targets

HUBDesign: A bioinformatic pipeline for designing probes capable of capturing broad targets of interest in metagenomic settings.

Pleistocene mitogenomes reconstructed from the environmental DNA of permafrost sediments

No bones about it: assembling mitochondrial genomes of Pleistocene fauna over 40,000 years from open-air sediments allows for the phylogenetic analysis of ...

Plagued by a cryptic clock: insight and issues from the global phylogeny of Yersinia pestis

Pandemic Y. pestis lineages emerged decades before being historically documented from European sources.

Molecular caving

Since fecal remnants are probably one of the major components of dry cave sediments, we decided to extract ancient DNA from the sediment of Rampart Cave, ...

Molecular Analyses of Oral Polio Vaccine Samples

We analyzed several early oral polio vaccine pools to test the "OPV/AIDS hypothesis". Our analysis found no evidence for the presence of chimpanzee DNA, but ...

Single nucleotide polymorphism (SNP) discovery in mammals: a targeted-gene approach

Here we describe the use of 'CATS' (or 'EPIC') primers for the detection of novel SNPs in non-model mammals. We observed that PCR success was highest in ...